Noveome Biotherapeutics, Inc. Doses First Patient in Phase 2 Open Label Clinical Trial Evaluating Topical Ocular Delivery of ST266 For the Treatment of Persistent Corneal Epithelial Defects

Topline results expected by end of 2019
PITTSBURGH, PA – June 13, 2019 – Noveome Biotherapeutics, Inc., a clinical-stage biopharmaceutical company focused on developing next-generation biologics for the promotion and restoration of cellular integrity of inflamed or damaged tissues, today announced the dosing of the first patient in its Phase 2 open label, multi-center clinical trial evaluating topical ocular delivery of ST266 for the treatment of persistent corneal epithelial defects (PEDs), for which there are limited treatment options.

“The dosing of the first patient in our Phase 2 clinical trial marks an important milestone for Noveome as we continue to explore ST266’s safety, efficacy and broad therapeutic applicability. We believe that ST266 has the potential to provide an innovative treatment option as a novel cell-free platform biologic based on the results we have seen to date in both preclinical and clinical trials demonstrating a strong safety profile,” said William J. Golden, Founder, Chairman and Chief Executive Officer of Noveome. “In this trial, we will measure both the magnitude and speed of response, as well as the number of completely healed patients and the time to complete healing in the study eye of PED patients.”

The Phase 2 open label, multi-center clinical trial will evaluate the safety and efficacy of topical delivery of ST266 in patients with PEDs. The primary endpoint of the clinical trial is to complete healing as determined by fluorescein dye after 28 days of therapy. Each patient will receive a total of 4 doses per day of ST266 over the course of 28 days in the study eye. More information about the study is available at www.clinicaltrials.gov under the identifier NCT03687632. Topline results are expected later in 2019.

About Persistent Corneal Epithelial Defects (PEDs)
PEDs are non-healing wounds of the cornea caused by trauma, surgery and infection for which there are limited treatment options. Failure of the epithelial cells in the cornea to migrate and close the wound can lead to scarring and possibly perforation and blindness, especially in patients with severe dry eye and diabetes.

About ST266
ST266 is a cell-free “platform” biologic containing hundreds of proteins and other factors involved in cellular healing, protection of the brain and nerves, and modulation of inflammation. The components of ST266 are secreted by a novel population of cells generated by a proprietary method of culturing amnion-derived epithelial cells collected from full term placentas, which are normally discarded after birth. This “secretome” contains physiologic levels of multiple growth factors and cytokines and stimulates a variety of anti-inflammatory and neuroprotective responses in preclinical studies. In addition to central nervous system (CNS) conditions, ST266 is being evaluated in ophthalmologic, pulmonary and gastrointestinal conditions. The ST266 platform biologic enables the use of a scalable manufacturing process to produce quantities for all indications, A drug master file has been submitted with the FDA, supporting all ST266 investigational new drug (IND) applications.

About Noveome Biotherapeutics, Inc.
Noveome Biotherapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing next-generation biologics for the promotion and restoration of cellular integrity of inflamed or damaged tissues. Noveome’s multi-target platform biologic and lead product, ST266, is currently being evaluated in multiple indications across CNS, ophthalmic, pulmonary and gastrointestinal therapeutic areas. Noveome is planning to start a Phase 1 open label clinical trial to establish the safety of ST266 when delivered intranasally in 2Q 2019 as well as a Phase 2/3 clinical trial of ST266 in patients with cataracts in 4Q 2019. In addition to the clinical pipeline, preclinical results testing ST266 in chronic traumatic encephalopathy (CTE), emphysema and necrotizing enterocolitis (NEC) are also expected later in 2019. The Company received seed funding from Lancet Capital, a venture capital consortium of leading Pittsburgh healthcare institutions including UPMC Enterprises, Highmark Blue Cross/Blue Shield, University of Pittsburgh and Carnegie Mellon University. To date, Noveome has received over $120 million in research and infrastructure funding from the U.S. Department of Defense, the Commonwealth of Pennsylvania and Allegheny County. Noveome is based in Pittsburgh, PA. For more information, please visit, www.noveome.com.
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Investor Contact:
Julie Seidel
Stern Investor Relations, Inc.
212-362-1200
julie.seidel@sternir.com

Noveome Biotherapeutics, Inc. Announces Publication of Further Preclinical Results Supporting the Neuroprotective Properties of ST266 in Retinal Ganglion Cells

PITTSBURGH, PA – May 9, 2019 – Noveome Biotherapeutics, Inc., a clinical-stage biopharmaceutical company focused on developing next-generation biologics for the promotion and restoration of cellular integrity of inflamed or damaged tissues, today announced the publication of preclinical results for ST266, its proprietary, cell-free platform biologic, published in the Journal of Neuro-Ophthalmology. These new results further support the neuroprotective properties of intranasally delivered ST266 in mice with experimental autoimmune encephalomyelitis (EAE)-induced experimental optic neuritis (ON).

The publication entitled, “Effects of Varying Intranasal Treatment Regimens in ST266-Mediated Retinal Ganglion Cell Neuroprotection,” details the preclinical study exploring the neuroprotective effects of daily and twice daily intranasally delivered ST266 to evaluate different treatment regimens an EAE-induced experimental ON mouse model.

“In previous studies, we showed that a single daily dose of ST266 administered through the nose diminished visual dysfunction, prevented retinal ganglion cell loss, and reduced both inflammation and demyelination six weeks after induction of EAE,” said Larry Brown, Sc.D., Noveome’s Chief Scientific Officer.

Kenneth S. Shindler, M.D., Ph.D., an associate professor of Ophthalmology in the Perelman School of Medicine at the University of Pennsylvania and Penn’s Scheie Eye Institute, and senior author on the paper continued, “In this study we demonstrated the ability of ST266 to confer longer-term neuroprotective effects, by showing that EAE mice that received either once or twice daily intranasal drops of ST266 starting from day 15 and repeated through day 56 showed significant preservation of vision, significant preservation of retinal ganglion cells, and significant reduction in optic nerve inflammation.”

“We are pleased to see these strong preclinical results that further validate this approach to non-cellular therapeutic treatment for optic nerve diseases. These results demonstrate the promise of our novel platform biologic, in which the multiple growth factors and anti-inflammatory cytokines present in ST266 are able to achieve neuroprotective benefits in varying intranasal treatment regimens,” said William J. Golden, Founder, Chairman and Chief Executive Officer of Noveome. “With this foundational science in hand, we look forward to further exploring ST266’s neuroprotective properties in our growing CNS pipeline with data from our Phase 1 clinical trial of intranasal ST266 in patients at risk of developing optic nerve disease expected later this year.”

About Noveome Biotherapeutics, Inc.
Noveome Biotherapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing next-generation biologics for the promotion and restoration of cellular integrity of inflamed or damaged tissues. Noveome’s multi-target platform biologic and lead product, ST266, is a complex, non-cellular product containing hundreds of biologically active proteins and other biologic factors. ST266 is currently being evaluated in multiple indications across CNS, ophthalmic, pulmonary and gastrointestinal therapeutic areas. Topline data from an ongoing Phase 1 trial using a novel intranasal delivery method to deliver ST266 to the optic nerve and brain and an ongoing Phase 2 trial in corneal defects are expected later in 2019. In addition, preclinical results testing ST266 in chronic traumatic encephalopathy, emphysema and necrotizing enterocolitis are also expected later in 2019. The Company received seed funding from Lancet Capital, a venture capital consortium of leading Pittsburgh healthcare institutions including UPMC Enterprises, Highmark Blue Cross/Blue Shield, University of Pittsburgh and Carnegie Mellon University. To date, Noveome has received over $120 million in research and infrastructure funding from the U.S. Department of Defense, the Commonwealth of Pennsylvania and Allegheny County. Noveome is based in Pittsburgh, PA. For more information, please visit, www.noveome.com.

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Investor Contact:
Julie Seidel
Stern Investor Relations, Inc.
212-362-1200
julie.seidel@sternir.com

Noveome Biotherapeutics, Inc. Completes $15 Million Series D Financing to Advance Growing Pipeline of Next-Generation Biologics

PITTSBURGH, PA – April 9, 2019 – Noveome Biotherapeutics, Inc., a Pittsburgh-based biopharmaceutical company in clinical-stages focused on developing next-generation biologics for the promotion and restoration of cellular integrity of inflamed or damaged tissues, today announced the closing of a $15 million Series D financing. The financing was led by a new institutional investor in addition to existing investors. Prior to this Series D financing, Noveome has raised a total of $144 million in capital from both private equity investors and non-dilutive capital from the U.S. Department of Defense and the Commonwealth of Pennsylvania and Allegheny County.

Proceeds from the financing will be used to support the advancement of the Company’s clinical stage programs investigating its proprietary, cell-free platform biologic, ST266, for the treatment of both ophthalmological and central nervous system (CNS) disorders.

“We are encouraged by the support from both our new and existing investors in this Series D financing, providing Noveome with the necessary funding to progress our clinical stage ophthalmological and CNS disorder programs into further clinical studies, in addition to advancing our broader pipeline of exciting indications,” said William J. Golden, Founder, Chairman and Chief Executive Officer of Noveome Biotherapeutics, Inc. “We look forward to executing on the promise of our growing pipeline, focusing on the potential broad therapeutic applicability of our novel, cell-free platform biologic, ST266, as we work to deliver novel treatment methods to patients suffering from a wide variety of complex diseases.”

About Noveome Biotherapeutics, Inc.
Noveome Biotherapeutics, Inc. is a Pittsburgh-based biopharmaceutical company in clinical-stages focused on developing next-generation biologics for the promotion and restoration of cellular integrity of inflamed or damaged tissues. Noveome’s multi-target platform biologic and lead product, ST266, is a complex, non-cellular product containing hundreds of biologically active proteins and other biologic factors. ST266 is currently being evaluated in multiple indications across CNS, ophthalmic, pulmonary and gastrointestinal therapeutic areas. Topline data from an ongoing Phase 1 trial using a novel intranasal delivery method to deliver ST266 to the optic nerve and brain and an ongoing Phase 2 trial in corneal defects are expected later in 2019. In addition, preclinical results testing ST266 in chronic traumatic encephalopathy, emphysema and necrotizing enterocolitis are also expected later in 2019. The Company received seed funding from Lancet Capital, a venture capital consortium of leading Pittsburgh healthcare institutions including UPMC Enterprises, Highmark Blue Cross/ Blue Shield, University of Pittsburgh and Carnegie Mellon University. To date, Noveome has received over $120 million in research and infrastructure funding from the U.S. Department of Defense, the Commonwealth of Pennsylvania and Allegheny County. Noveome is based in Pittsburgh, PA. For more information, please visit, www.noveome.com.

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Investor Contact:
Julie Seidel
Stern Investor Relations, Inc.
212-362-1200
julie.seidel@sternir.com
https://www.bizjournals.com/pittsburgh/news/2019/04/22/this-pittsburgh-biotechcompany-just-raised-15m.html

Noveome Biotherapeutics, Inc. to Present at the 18th Annual Needham Healthcare Conference

PITTSBURGH, PA – April 2, 2019 – Noveome Biotherapeutics, Inc., a clinical-stage biopharmaceutical company focused on developing next-generation biologics for the promotion and restoration of cellular integrity of inflamed or damaged tissues, announced today that William J. Golden, Founder, Chairman and Chief Executive Officer of Noveome Biotherapeutics, Inc., will present a company overview at the 18th Annual Needham Healthcare Conference on Tuesday, April 9, 2019 at 10:20 a.m. EDT in New York, NY.

About Noveome Biotherapeutics, Inc.
Noveome Biotherapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing next-generation biologics for the promotion and restoration of cellular integrity of inflamed or damaged tissues. Noveome’s multi-target platform biologic and lead product, ST266, is a complex, non-cellular product containing hundreds of biologically active proteins and other biologic factors. ST266 is currently being evaluated in multiple indications across CNS, ophthalmic, pulmonary and gastrointestinal therapeutic areas. Topline data from an ongoing Phase 1 trial using a novel intranasal delivery method to deliver ST266 to the optic nerve and brain and an ongoing Phase 2 trial in corneal defects are expected later in 2019. In addition, preclinical results testing ST266 in chronic traumatic encephalopathy, emphysema and necrotizing enterocolitis are also expected later in 2019. The Company received seed funding from Lancet Capital, a venture capital consortium of leading Pittsburgh healthcare institutions including UPMC Enterprises, Highmark Blue Cross/ Blue Shield, University of Pittsburgh and Carnegie Mellon University. To date, Noveome has received over $120 million in research and infrastructure funding from the U.S. Department of Defense, the Commonwealth of Pennsylvania and Allegheny County. Noveome is based in Pittsburgh, PA. For more information, please visit, www.noveome.com.

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Investor Contact
Julie Seidel
Stern Investor Relations, Inc.
212-362-1200
julie.seidel@sternir.com

Study Advances Novel Treatment for Damaged Optic Nerve

Preclinical Data Suggests Use Beyond Conditions of the Eye
PITTSBURGH – May 24, 2018 – A newly published scientific study has demonstrated that damage to the optic nerve can be significantly reduced, with the potential for improved visual function, when treated with ST266, the lead product of Noveome Biotherapeutics, Inc.

The preclinical study involved animals with a crushed optic nerve, a condition humans can experience through head injury or eye disease.

Currently there are no existing treatments to lessen or reverse damage and vision loss resulting from optic nerve trauma, and no existing methods are able to restore the function of the optic nerve.

The research was conducted in collaboration with Kenneth S. Shindler, M.D., Ph.D., a professor of Ophthalmology in the Perelman School of Medicine at the University of Pennsylvania.

The findings were published this week in Investigative Ophthalmology and Visual Science in an article titled, “RGC Neuroprotection Following Optic Nerve Trauma Mediated by Intranasal Delivery of Amnion Cell Secretome.” http://iovs.arvojournals.org/article.aspx?articleid=2681860

“These results offer hope for this untreatable cause of permanent vision loss,” said Dr. Shindler. “Further testing and development of this novel therapy may provide an opportunity to reduce future vision loss and neurologic disability in a host of diseases that currently have little or no treatment options.”

Wider Implications
ST266 is a rich, complex solution of biologically active molecules secreted from Noveome’s proprietary cells. Instead of a single drug and target, ST266 targets numerous pathways involved in the regenerative repair of inflamed or damaged tissues.
In the study, Dr. Shindler administered ST266 non-invasively through the nasal passages such that the ST266 reached the olfactory nerve in the back of the nose. This method allows ST266 to be delivered directly to the optic nerve and brain, a different route than traditional intranasal delivery that requires absorption of drugs through nasal tissue into the bloodstream.
Dr. Shindler found that ST266 significantly reduced damage to the optic nerve, as measured by a standard vision test called optokinetic response (OKR). Furthermore, showing a trend toward improved visual function and more active nerve cells, ST266 increased survival of the retinal ganglion cells (RGCs) that transmit visual signals from the eye to the brain.

Noveome’s Chief Scientific Officer, Larry R. Brown, Sc.D., sees even greater possibilities for delivery of ST266 based on these results. “These promising results reinforce the multifaceted potential of targeted ST266 in multiple neurodegenerative conditions of the brain including traumatic brain injury, chronic traumatic encephalopathy, or diseases such as Alzheimer’s Disease, Parkinson’s Disease, amyotrophic lateral sclerosis and stroke,” said Dr. Brown.

The model used in this study is particularly useful for testing therapies for glaucoma, where increased eye pressure can damage the optic nerve, and for vision problems that afflict a majority of military service personnel who have been diagnosed with traumatic brain injury. Both glaucoma and traumatic optic nerve injury can lead to severe or even permanent vision loss.
Later this year, Noveome plans to begin a Phase 1 clinical human safety trial for targeted delivery of ST266 deep into the nasal passages, in collaboration with the Israeli medical device maker SipNose and through funding provided by the Commonwealth of Pennsylvania.

Editor’s Note: Shindler has served as a scientific advisory board member and consultant to Noveome and has received funds from Noveome for his consulting services. In addition, Noveome has provided unrestricted funds to Penn to support research in Shindler’s laboratory.

About ST266
ST266 is a novel secretome developed and manufactured by Noveome in its GMP manufacturing facility in Pittsburgh, Pennsylvania. In multiple preclinical studies, ST266 has demonstrated unique attributes of modulating inflammation, restoring nerve function, speeding impaired wound healing, and restoring cellular homeostasis, indicating that it can be applied across a wide range of disease indications to improve patient outcomes. Noveome has already treated 233 subjects with ST266 in eight clinical trials in various indications. It was found to be well-tolerated and there were no drug-related adverse events reported, attesting to its strong safety profile. Previous studies using an optic neuritis model were reported in Scientific Reports volume 7, Article number: 41768 (2017).

About Noveome
Noveome is a clinical stage company focused on breakthrough therapies for the regenerative repair of inflamed or damaged tissues. The company, formerly called Stemnion, Inc., is located in the heart of Pittsburgh’s riverfront Technology Center. The company received seed money from UPMC Enterprises, University of Pittsburgh and Carnegie Mellon University when it was founded in 2000. To date, Noveome has received $114 million in research funding, primarily from the U.S. Department of Defense as well as other state and county government agencies. Noveome is passionate about growing its business in Allegheny County and helping the region to become a world leader in biotechnology research and development. www.noveome.com.

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CONTACT:
Noveome Biotherapeutics, Inc.
Gail Kempler, Ph.D., (412) 402-9914
Director, Investor Relations
gkempler@noveome.com

Media Inquiries:
Rich Creehan
(412) 341-1607
creehanmedia@gmail.com

Patrick Welch Elected to Noveome Board of Directors

PITTSBURGH—April 27, 2018— Noveome Biotherapeutics, Inc. has named a veteran executive in pharmaceutical marketing and sales, Patrick Welch, to a new seat on its Board of Directors.

Welch brings to Noveome his expertise gained in more than three decades in the pharmaceutical industry and healthcare management consulting. He spent 27 years at Allergan, Inc., the global pharmaceutical company, serving as a vice-president managing various corporate marketing operations in both the U.S. and Asia. Currently, Welch is president of Loudon, Tennessee-based WeGo Consulting, LLC, which he founded in 2014.

“Pat is an ideal individual to join the Noveome board, as he has an outstanding track record for pre-approval planning, sales and marketing of drugs for complex eye diseases,” said William J. Golden, Noveome’s founder and board chairman. “We are extremely pleased to have him at this critical point in Noveome’s development.”

Noveome recently announced plans to begin clinical trials on its product, ST266, for the treatment of currently untreatable diseases of the brain and eye. ST266 is a complex solution of molecules secreted from novel cells grown using Noveome’s proprietary process. It is being tested for its ability to safely control inflammation, protect and resuscitate nerve cells, and speed healing. To date the company has raised $114 million for research and manufacturing from the U.S. Department of Defense and other state and county government agencies.

“I am honored to join the Noveome Board of Directors and look forward to working with its distinguished members to help guide development, sales and marketing of the company’s promising drug candidate ST266,” said Welch.

Several of Welch’s accomplishments at Allergan relate directly to Noveome’s current focus on optic nerve disease. He was vice-president overseeing Allergan’s US Retina business unit. Previously, he directed Allergan’s entire Glaucoma portfolio, and managed the pre-approval planning for the drug RESTASIS® for treating dry eye (Allergan’s most successful eye drug) and LUMIGAN® for high eye pressure. Beyond ophthalmology, he was involved in Allergan operations concerning medical dermatology, neuroscience, healthcare reimbursement, and government affairs. He was a vice-president and general manager for Allergan Korea, and managing director for Asia.

About Noveome Biotherapeutics, Inc.
Noveome is a clinical stage company focused on breakthrough therapies for the regenerative repair of inflamed or damaged tissues. The company, formerly called Stemnion, Inc., is located in the heart of Pittsburgh’s riverfront Technology Center. The company originally received seed money from UPMC Enterprises, University of Pittsburgh and Carnegie Mellon University when it was founded in 2000.

Contacts
Noveome Biotherapeutics, Inc.
Gail Kempler, Ph.D., (412) 402-9914
Director, Investor Relations
gkempler@noveome.com

Media Inquiries:
Rich Creehan
(412) 341-1607
creehanmedia@gmail.com

State Grant to Fund Clinical Trials Through Pittsburgh-Israeli Collaboration

PITTSBURGH —April 3, 2018— Noveome Biotherapeutics, Inc. has been awarded a significant grant from the Commonwealth of Pennsylvania to begin clinical trials for eye and brain diseases.

The $500,000 grant comes from the Pennsylvania Department of Health. The clinical trials will focus on potential remedies for currently untreatable back of the eye conditions including glaucoma and optic neuritis, and for a type of brain damage known as chronic traumatic encephalopathy, or CTE.

Pittsburgh-based Noveome intends to conduct the trials in collaboration with SipNose, Ltd. of Yokneam, Israel. Noveome has developed a proprietary product, called ST266, for healing damaged or diseased tissue. SipNose has developed a unique device that can deliver ST266 non-invasively through the nose to protect nerves in the affected areas of the eye or brain.

The two companies entered into a formal collaboration agreement last month for using ST266 with the nasal device. They have already completed preclinical studies. A Phase 1 clinical safety trial is scheduled to begin later this year.

Their collaboration comes at the same time that Pennsylvania has been seeking to promote more research and development projects involving local and Israeli companies. The Commonwealth and the State of Israel just signed an Agreement on Cooperation in Research, Development and Technological Innovation in November 2017.

“It is very timely and exciting to have an established Pittsburgh biotech company and an innovative Israeli company collaborating on this critical life sciences project,” said Dennis M. Davin, Secretary of the Pennsylvania Department of Community and Economic Development.

Marc Zucker, Chairman, Pennsylvania Jewish Coalition, commented, “The Pennsylvania Jewish Coalition worked tirelessly last year to consummate a memorandum of understanding between Israel and the Commonwealth of Pennsylvania. This latest development demonstrates how businesses in Israel and Pennsylvania, when given the opportunity, can build bridges of understanding and mutual cooperation, for the benefit of all concerned.” For several years, his organization and others have been working with the Commonwealth and the Israeli Consulate’s office to encourage such joint ventures.

Jeff Finkelstein, President of the Jewish Federation of Pittsburgh echoed, “Pittsburgh and Israel have many connections through technology and medical companies that employ experts across countries. This development attests to the growth potential for partnerships between the thriving tech community in Pittsburgh and the ‘startup nation’ of Israel.”

The Diseases and Potential Treatment
Intranasal ST266 will be used for diseases of the nerve that connects the eye to the brain including glaucoma and multiple sclerosis (MS). Glaucoma damages the optic nerve and is a leading cause of blindness for people over 60 years old. Current treatments slow the nerve damage, but do not prevent it. With MS, the body’s immune system attacks the protective sheath covering the optic nerve resulting in optic neuritis. Optic neuritis is often the first symptom associated with MS. There is no treatment for this MS related eye condition.

Intranasal ST266 will also be tested as a treatment for chronic traumatic encephalopathy (CTE). CTE is a degenerative disease usually caused by repeated head injuries. Most documented cases occur in athletes involved in contact sports and in combat injuries. Symptoms may range from headaches and dizziness, to changes in mood and behavior, and in some cases, dementia and even suicide. Autopsies have revealed a buildup of tau proteins that have damaged the brain tissue.

In all of these indications, Noveome’s ST266 will be tested for its ability to control inflammation, protect and resuscitate nerve cells, and speed impaired healing. ST266 is a complex solution of molecules secreted from novel cells grown using Noveome’s proprietary process. Unlike a single drug used for a single target, ST266 contains such a complex combination of biologically active molecules that it may be useful for treating many different diseases and conditions.

“We are confident that we will be successful in delivering ST266 directly to the back of the eye and brain,” said William J. Golden, Founder, Chairman and CEO at Noveome. “Combining our product with SipNose’s innovative medical device represents a revolutionary approach to non-invasively treat currently untreatable medical conditions.”

Noveome has already treated 233 subjects with ST266 in eight clinical trials in other indications. It was found to be well-tolerated and there were no drug-related adverse events reported, attesting to its strong safety profile.

A Common Connection Leads to Collaboration
Noveome’s collaboration with SipNose was initiated by Dr. Larry Brown, CSO of Noveome, and Dr. Iris Shichor, CEO of SipNose. They met through the Massachusetts Institute of Technology, where both studied under Dr. Robert Langer, a distinguished Institute Professor and a member of Noveome’s Board of Directors.

Dr. Langer commented, “I am always heartened when my prior students join forces by innovating new and exciting approaches to address untreatable conditions such as optic neuropathies and brain diseases.”

About Noveome
Noveome is a clinical stage company focused on breakthrough therapies for the regenerative repair of inflamed or damaged tissues. The company, formerly called Stemnion, Inc., is located in the heart of Pittsburgh’s riverfront Technology Center. The company originally received seed money from UPMC Enterprises, University of Pittsburgh and Carnegie Mellon University when it was founded in 2000. To date, Noveome has received $109 million in research funding from the U.S. Department of Defense. Noveome is passionate about growing its business in Allegheny County and helping the region to become a world leader in biotechnology research and development. www.noveome.com

About SipNose
Founded in Yokneam, Israel in 2011, SipNose is a medical device company that has developed an innovative targeted intranasal delivery device for non-invasively delivering medicines to the brain. SipNose is developing novel applications for unmet need clinical conditions through its collaborations with pharmaceutical companies and academia leaders.

Contacts
Noveome Biotherapeutics, Inc.
Gail Kempler, Ph.D., (412) 402-9914
Director, Investor Relations
gkempler@noveome.com

SipNose, Ltd.
Eric Keller, (703) 624-2024
Director of Business Development
eric@sipnose.com

Media Inquiries:
Rich Creehan
(412) 341-1607
creehanmedia@gmail.com